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Moreover, iMQT_020 not only has global antitumor effects by inducing metabolic crisis through blocking the essential mitochondrial glutamine transport function of SLC1A5_var for cancer metabolism, but also increases the antitumor immune function of T cells in combination with anti-PD-L1 via epigenetic modulation of PD-L1 expression in pancreatic cancer cells

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C.MordorskiB.NosanchukJ.FriedmanJ